- Title
- Zn-Loaded SBA-1 and SBA-15 Molecular Sieves for Combined Antimicrobial and Osteogenic Activity
- Creator
- Trinh, Hoang Trung; Tran, Thi Kim Anh; Arora, Shuchi; George, Suchi Mercy; Sheri, Jolitta; Li, Zhixuan; Yang, Jae-Hun; Naruphontjirakul, Parichart; Balani, Kantesh; Karakoti, Ajay; Vinu, Ajayan
- Relation
- Advanced Materials Technologies Vol. 8, Issue 6, no. 2201169
- Publisher Link
- http://dx.doi.org/10.1002/admt.202201169
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2023
- Description
- Mesoporous silica-based materials are currently being explored as a new type of bioscaffold for bone regeneration applications. Zinc(Zn) ion incorporation is shown to play an important role in promoting bone regeneration and also providing antimicrobial activity to the scaffold materials. In this work, the role of pore size, geometry, and ordered structure on the Zn loading and release performance of two different mesoporous silica, SBA-1 and SBA-15, are compared. Zn loading is varied from 2.5 to 10 wt% for both samples, and its effect on the antibacterial and osteogenic activity is evaluated. Zn loading up to 10 wt% has a negligible effect on the morphology and textural properties of the mesoporous silica samples. The inductively coupled plasma mass spectrometry (ICP-MS) analysis reveals that SBA-15 exhibits significantly higher Zn release in Luria-Bertani (LB) broth as compared to SBA-1 that is reflected in the higher antibacterial activity of SBA-15 against both gram-positive and gram-negative bacteria. Various assays show that 5 wt% Zn loading is sufficient to produce both bactericidal and inhibitory effects on bacterial cells. The 5 wt% Zn-loaded samples induce osteogenic differentiation ofavianized bone marow-derived stromal cells (TVA-BMSCs) though SBA-15 samples show better compatibility compared to SBA-1, suggesting that Zn incorporation can produce sufficient antibacterial effect and osteogenic differentiation of TVA-BMSCs.
- Subject
- antibacterial; mesoporous silica; osteogenic differentation; SBA-1; SBA-15; zinc adsorption
- Identifier
- http://hdl.handle.net/1959.13/1480471
- Identifier
- uon:50510
- Identifier
- ISSN:2365-709X
- Rights
- © 2023 The Authors. Advanced Materials Technologies published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Language
- eng
- Full Text
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